Journal of Translational Medicine (2024)

Table of Contents
NIPU: a randomised, open-label, phase II study evaluating nivolumab and ipilimumab combined with UV1 vaccination as second line treatment in patients with malignant mesothelioma Patient-derived organoid (PDO) platforms to facilitate clinical decision making The clinical application of electrical impedance technology in the detection of malignant neoplasms: a systematic review Clinical application of the AUC-guided dosage adjustment of docetaxel-based chemotherapy for patients with solid tumours: a single centre, prospective and randomised control study Tissue microRNAs in non-small cell lung cancer detected with a new kind of liquid bead array detection system Tianzhi granule improves cognition and BPSD of vascular dementia: a randomized controlled trial Microbiota, type 2 diabetes and non-alcoholic fatty liver disease: protocol of an observational study A Phase I/II trial comparing autologous dendritic cell vaccine pulsed either with personalized peptides (PEP-DC) or with tumor lysate (OC-DC) in patients with advanced high-grade ovarian serous carcinoma Complementary biobank of rodent tissue samples to study the effect of World Trade Center exposure on cancer development Visceral adipose accumulation increased the risk of hyperuricemia among middle-aged and elderly adults: a population-based study Tissue diagnosis during colorectal cancer surgery using optical sensing: an in vivo study Serial plasma DNA levels as predictors of outcome in patients with acute traumatic cervical spinal cord injury Undetectable circulating tumor DNA (ctDNA) levels correlate with favorable outcome in metastatic melanoma patients treated with anti-PD1 therapy A randomized, placebo-controlled, double-blinded, single-centre, phase IV trial to assess the efficacy and safety of OM-85 in children suffering from recurrent respiratory tract infections CDK4/6 inhibitor palbociclib suppresses IgE-mediated mast cell activation Renal temperature reduction progressively favors mitochondrial ROS production over respiration in hypothermic kidney preservation Genome-wide profiling reveals alternative polyadenylation of mRNA in human non-small cell lung cancer Frequent genetic aberrations in the cell cycle related genes in mucosal melanoma indicate the potential for targeted therapy Impact of probiotics on pathogen survival in an innovative human plasma biofilm model (hpBIOM) Wolfram syndrome, a rare neurodegenerative disease: from pathogenesis to future treatment perspectives Development of a novel ssDNA aptamer targeting neutrophil gelatinase-associated lipocalin and its application in clinical trials Orthostatic intolerance in chronic fatigue syndrome Pre-clinical evaluation of Minnelide as a therapy for acute myeloid leukemia Blood cell transcript levels in 5-year-old children as potential markers of breastfeeding effects in those small for gestational age at birth Remote ischemic preconditioning attenuates intestinal mucosal damage: insight from a rat model of ischemia–reperfusion injury RIPK1 suppresses apoptosis mediated by TNF and caspase-3 in intervertebral discs Compound α-keto acid tablet supplementation alleviates chronic kidney disease progression via inhibition of the NF-kB and MAPK pathways Spray drying OZ439 nanoparticles to form stable, water-dispersible powders for oral malaria therapy Dermal tissue remodeling and non-osmotic sodium storage in kidney patients Diagnostic sensitivity of 2-day cardiopulmonary exercise testing in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Chromosome screening using culture medium of embryos fertilised in vitro: a pilot clinical study Evaluation of endoscopic visible light spectroscopy: comparison with microvascular oxygen tension measurements in a porcine model How stakeholder engagement influenced a randomized comparative effectiveness trial testing two Diabetes Prevention Program interventions in a Marshallese Pacific Islander Community Revisiting IDO and its value as a predictive marker for anti-PD-1 resistance Systemic immune-inflammation index predicts prognosis of patients with advanced pancreatic cancer In vitro effects of interleukin (IL)-1 beta inhibition on the epithelial-to-mesenchymal transition (EMT) of renal tubular and hepatic stellate cells An innovative total temporomandibular joint prosthesis with customized design and 3D printing additive fabrication: a prospective clinical study FGFR1 expression defines clinically distinct subtypes in pancreatic cancer Diffusion-weighted imaging and diffusion kurtosis imaging for early evaluation of the response to docetaxel in rat epithelial ovarian cancer Autoimmune disorders but not heparin are associated with cell-free fetal DNA test failure Mutational and phenotypic spectrum of OTOF-related auditory neuropathy in Koreans: eliciting reciprocal interaction between bench and clinics Therapeutic value of surgical paraaortic staging in locally advanced cervical cancer: a multicenter cohort analysis from the FRANCOGYN study group Possibility of avoiding axillary lymph node dissection by immune microenvironment monitoring in preoperative chemotherapy for breast cancer Significance of intrinsic breast cancer subtypes on the long-term prognosis after neoadjuvant chemotherapy Is it possible to overcome issues of external validity in preclinical animal research? Why most animal models are bound to fail Podocalyxin-like protein as a predictive biomarker for benefit of neoadjuvant chemotherapy in resectable gastric and esophageal adenocarcinoma Analysis of circulating tumour cell and the epithelial mesenchymal transition (EMT) status during eribulin-based treatment in 22 patients with metastatic breast cancer: a pilot study The development of a Biobank of cancer tissue samples from World Trade Center responders The role of diffusion tensor imaging as an objective tool for the assessment of motor function recovery after paraplegia in a naturally-occurring large animal model of spinal cord injury The diagnostic value of [18F]-FDG-PET/CT in assessment of radiation renal injury in Tibet minipigs model
  • NIPU: a randomised, open-label, phase II study evaluating nivolumab and ipilimumab combined with UV1 vaccination as second line treatment in patients with malignant mesothelioma

    Malignant pleural mesothelioma (MPM) is a rare and aggressive tumour. For patients with inoperable disease, few treatment options are available after first line chemotherapy. The combination of ipilimumab and ...

    Authors: Vilde Drageset Haakensen, Anna K. Nowak, Espen Basmo Ellingsen, Saima Jamil Farooqi, Maria Moksnes Bjaanæs, Henrik Horndalsveen, Tine Mcculloch, Oscar Grundberg, Susana M. Cedres and Åslaug Helland

    Citation: Journal of Translational Medicine 2021 19:232

    Content type: Protocol Published on: 31 May 2021

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  • Patient-derived organoid (PDO) platforms to facilitate clinical decision making

    Based on recent advances in organoid research as well as the need to find more accurate models for drug screening in cancer research, patient-derived organoids have emerged as an effective in vitro model syste...

    Authors: Lisa Liu, Lei Yu, Zhichao Li, Wujiao Li and WeiRen Huang

    Citation: Journal of Translational Medicine 2021 19:40

    Content type: Review Published on: 21 January 2021

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  • The clinical application of electrical impedance technology in the detection of malignant neoplasms: a systematic review

    Electrical impedance technology has been well established for the last 20years. Recently research has begun to emerge into its potential uses in the detection and diagnosis of pre-malignant and malignant cond...

    Authors: Angela A. Pathiraja, Ruwan A. Weerakkody, Alexander C. von Roon, Paul Ziprin and Richard Bayford

    Citation: Journal of Translational Medicine 2020 18:227

    Content type: Review Published on: 8 June 2020

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  • Clinical application of the AUC-guided dosage adjustment of docetaxel-based chemotherapy for patients with solid tumours: a single centre, prospective and randomised control study

    Docetaxel (DTX) is a widely used anti-tumour drug, and its dosage is solely determined by body surface area (BSA). Adverse events, such as neutropenia or unsatisfied efficacy, likely occur because of differenc...

    Authors: Ning Sun, Bo Shen, Jiali Zhu, Xiaomei Zhang, Huayun Zhu, Geyu Liang, Deliang Yang, Jianwei Lu and Yan Zhang

    Citation: Journal of Translational Medicine 2020 18:226

    Content type: Research Published on: 8 June 2020

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  • Tissue microRNAs in non-small cell lung cancer detected with a new kind of liquid bead array detection system

    Commonly used miRNA detection methods cannot be applied for high-throughput analyses. However, this study was aimed to performed a liquid bead array detection system (LBAS) to detect tissue 6 miRNAs in non-sma...

    Authors: Yuan-Yuan Zheng, Yun Fei, Zheng Wang, Yue Chen, Cheng Qiu and Fu-Rong Li

    Citation: Journal of Translational Medicine 2020 18:108

    Content type: Research Published on: 2 March 2020

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  • Tianzhi granule improves cognition and BPSD of vascular dementia: a randomized controlled trial

    Tianzhi granule (TZ) is usually used for patients with vascular dementia (VaD) in China. The aim was to assess the effect of TZ by a randomized clinical trial (RCT).

    Authors: Jing Shi, Mingqing Wei, Jingnian Ni, Feng Sun, Li Sun, Junfu Wang, Tao Yu, Kai Wang, Peiyuan Lv, Yunfu Wang, Yulian Zhang, Xuguang Gao, Xuanzhao Gao, Benyan Luo, Shanping Mao, Baorong Zhang…

    Citation: Journal of Translational Medicine 2020 18:76

    Content type: Research Published on: 13 February 2020

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  • Microbiota, type 2 diabetes and non-alcoholic fatty liver disease: protocol of an observational study

    Non-alcoholic fatty liver disease (NAFLD) is characterized by triglyceride accumulation in the hepatocytes in the absence of alcohol overconsumption, commonly associated with insulin resistance and obesity. Bo...

    Authors: Benedetta M. Motta, Christoph Grander, Martin Gögele, Luisa Foco, Vladimir Vukovic, Roberto Melotti, Christian Fuchsberger, Alessandro De Grandi, Chiara Cantaloni, Anne Picard, Deborah Mascalzoni, Alessandra Rossini, Cristian Pattaro, Herbert Tilg and Peter P. Pramstaller

    Citation: Journal of Translational Medicine 2019 17:408

    Content type: Protocol Published on: 4 December 2019

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  • A Phase I/II trial comparing autologous dendritic cell vaccine pulsed either with personalized peptides (PEP-DC) or with tumor lysate (OC-DC) in patients with advanced high-grade ovarian serous carcinoma

    Most ovarian cancer patients are diagnosed at a late stage with 85% of them relapsing after surgery and standard chemotherapy; for this reason, new treatments are urgently needed. Ovarian cancerhas become a c...

    Authors: Apostolos Sarivalasis, Caroline Boudousquié, Klara Balint, Brian J. Stevenson, Philippe O. Gannon, Emanuela Marina Iancu, Laetitia Rossier, Silvia Martin Lluesma, Patrice Mathevet, Christine Sempoux, George Coukos, Urania Dafni, Alexandre Harari, Michal Bassani-Sternberg and Lana E. Kandalaft

    Citation: Journal of Translational Medicine 2019 17:391

    Content type: Protocol Published on: 26 November 2019

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  • Complementary biobank of rodent tissue samples to study the effect of World Trade Center exposure on cancer development

    World Trade Center (WTC) responders were exposed to mixture of dust, smoke, chemicals and carcinogens. New York University (NYU) and Mount Sinai have recreated WTC exposure in rodents to observe the resulting ...

    Authors: Wil Lieberman-Cribbin, Stephanie Tuminello, Christina Gillezeau, Maaike van Gerwen, Rachel Brody, David J. Mulholland, Lori Horton, Maureen Sisco, Colette Prophete, Judith Zelikoff, Hyun-Wook Lee, Sung-Hyun Park, Lung-Chi Chen, Mitchell D. Cohen and Emanuela Taioli

    Citation: Journal of Translational Medicine 2019 17:342

    Content type: Research Published on: 11 October 2019

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  • Visceral adipose accumulation increased the risk of hyperuricemia among middle-aged and elderly adults: a population-based study

    The role of body fat distribution in uric acid metabolism is still ambiguity. We aimed to investigate the independent contribution of visceral adipose measured by visceral adiposity index and lipid accumulatio...

    Authors: Xiaolin Huang, Xiaohong Jiang, Long Wang, Lu Chen, Yang Wu, Pei Gao and Fei Hua

    Citation: Journal of Translational Medicine 2019 17:341

    Content type: Research Published on: 10 October 2019

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  • Tissue diagnosis during colorectal cancer surgery using optical sensing: an in vivo study

    In colorectal cancer surgery there is a delicate balance between complete removal of the tumor and sparing as much healthy tissue as possible. Especially in rectal cancer, intraoperative tissue recognition cou...

    Authors: E. J. M. Baltussen, S. G. Brouwer de Koning, J. Sanders, A. G. J. Aalbers, N. F. M. Kok, G. L. Beets, B. H. W. Hendriks, H. J. C. M. Sterenborg, K. F. D. Kuhlmann and T. J. M. Ruers

    Citation: Journal of Translational Medicine 2019 17:333

    Content type: Research Published on: 2 October 2019

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  • Serial plasma DNA levels as predictors of outcome in patients with acute traumatic cervical spinal cord injury

    Acute traumatic cervical spinal cord injury (SCI) is a leading cause of disability in adolescents and young adults worldwide. Evidence from previous studies suggests that circulating cell-free DNA is associate...

    Authors: Hung-Chen Wang, Yu-Tsai Lin, Shih-Yuan Hsu, Nai-Wen Tsai, Yun-Ru Lai, Ben Yu-Jih Su, Chia-Te Kung and Cheng-Hsien Lu

    Citation: Journal of Translational Medicine 2019 17:329

    Content type: Research Published on: 1 October 2019

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  • Undetectable circulating tumor DNA (ctDNA) levels correlate with favorable outcome in metastatic melanoma patients treated with anti-PD1 therapy

    Treatment with anti-PD1 monoclonal antibodies improves the survival of metastatic melanoma patients but only a subgroup of patients benefits from durable disease control. Predictive biomarkers for durable bene...

    Authors: Teofila Seremet, Yanina Jansen, Simon Planken, Hassan Njimi, Mélanie Delaunoy, Hakim El Housni, Gil Awada, Julia Katharina Schwarze, Marleen Keyaerts, Hendrik Everaert, Danielle Lienard, Véronique Del Marmol, Pierre Heimann and Bart Neyns

    Citation: Journal of Translational Medicine 2019 17:303

    Content type: Research Published on: 5 September 2019

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  • A randomized, placebo-controlled, double-blinded, single-centre, phase IV trial to assess the efficacy and safety of OM-85 in children suffering from recurrent respiratory tract infections

    Over many years, OM-85, a lysate of 21 common bacterial respiratory pathogens, has been demonstrated to prevent respiratory recurrences in children. However, further studies are needed to explore the true impo...

    Authors: Susanna Esposito, Sonia Bianchini, Samantha Bosis, Claudia Tagliabue, Ilaria Coro, Alberto Argentiero and Nicola Principi

    Citation: Journal of Translational Medicine 2019 17:284

    Content type: Research Published on: 23 August 2019

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  • CDK4/6 inhibitor palbociclib suppresses IgE-mediated mast cell activation

    Mast cell activation causes degranulation and release of cytokines, thereby promoting inflammation. The aim of this study was to investigate the inhibitory effect of CDK4/6 inhibition on mast cell activation i...

    Authors: Yi-Bo Hou, Kunmei Ji, Yue-Tong Sun, Li-Na Zhang and Jia-Jie Chen

    Citation: Journal of Translational Medicine 2019 17:276

    Content type: Research Published on: 20 August 2019

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  • Renal temperature reduction progressively favors mitochondrial ROS production over respiration in hypothermic kidney preservation

    Hypothermia, leading to mitochondrial inhibition, is widely used to reduce ischemic injury during kidney preservation. However, the exact effect of hypothermic kidney preservation on mitochondrial function rem...

    Authors: Koen D. W. Hendriks, Isabel M. A. Brüggenwirth, Hanno Maassen, Albert Gerding, Barbara Bakker, Robert J. Porte, Robert H. Henning and Henri G. D. Leuvenink

    Citation: Journal of Translational Medicine 2019 17:265

    Content type: Research Published on: 13 August 2019

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  • Genome-wide profiling reveals alternative polyadenylation of mRNA in human non-small cell lung cancer

    Lung cancer is the second most common cancer with an extremely poor overall survival rate. Post-transcriptional regulation of gene expression play many important roles in human cancer, and one of the potential...

    Authors: Shirong Zhang, Xiaochen Zhang, Wei Lei, Jiafeng Liang, Yasi Xu, Hailiang Liu and Shenglin Ma

    Citation: Journal of Translational Medicine 2019 17:257

    Content type: Research Published on: 7 August 2019

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  • Frequent genetic aberrations in the cell cycle related genes in mucosal melanoma indicate the potential for targeted therapy

    Melanoma is one of the most aggressive cancers with extremely poor prognosis, and the median survival time for stage IV patients is approximately 6 to 8months. Unlike cutaneous melanoma, mucosal melanoma is a...

    Authors: Longwen Xu, Zhiyuan Cheng, Chuanliang Cui, Xiaowen Wu, Huan Yu, Jun Guo and Yan Kong

    Citation: Journal of Translational Medicine 2019 17:245

    Content type: Research Published on: 29 July 2019

    The Correction to this article has been published in Journal of Translational Medicine 2019 17:358

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  • Impact of probiotics on pathogen survival in an innovative human plasma biofilm model (hpBIOM)

    Despite of medical advances, the number of patients suffering on non-healing chronic wounds is still increasing. This fact is attended by physical and emotional distress and an economic load. The majority of c...

    Authors: M. Besser, J. Terberger, L. Weber, B. Ghebremedhin, E. A. Naumova, W. H. Arnold and E. K. Stuermer

    Citation: Journal of Translational Medicine 2019 17:243

    Content type: Research Published on: 25 July 2019

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  • Wolfram syndrome, a rare neurodegenerative disease: from pathogenesis to future treatment perspectives

    Wolfram syndrome (WS), a rare genetic disorder, is considered the best prototype of endoplasmic reticulum (ER) diseases. Classical WS features are childhood-onset diabetes mellitus, optic atrophy, deafness, di...

    Authors: Maria Teresa Pallotta, Giorgia Tascini, Roberta Crispoldi, Ciriana Orabona, Giada Mondanelli, Ursula Grohmann and Susanna Esposito

    Citation: Journal of Translational Medicine 2019 17:238

    Content type: Review Published on: 23 July 2019

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  • Development of a novel ssDNA aptamer targeting neutrophil gelatinase-associated lipocalin and its application in clinical trials

    Neutrophil gelatinase-associated lipocalin (NGAL) is a promising biomarker of early diagnosis and prediction for acute kidney injury (AKI). However, the current program for NGAL detection is not extensively ap...

    Authors: Xiaoqian Hong, Huihui Yan, Fuan Xie, Kaiyu Wang, Qiang Wang, Huijuan Huang, Kunrong Yang, Suhong Huang, Tingting Zhao, Junkai Wang, Yunyun Chen, Kuancan Liu and Xiaopeng Lan

    Citation: Journal of Translational Medicine 2019 17:204

    Content type: Research Published on: 18 June 2019

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  • Orthostatic intolerance in chronic fatigue syndrome

    Orthostatic intolerance (OI) is a significant problem for those with chronic fatigue syndrome (CFS). We aimed to characterize orthostatic intolerance in CFS and to study the effects of exercise on OI.

    Authors: Richard Garner and James N. Baraniuk

    Citation: Journal of Translational Medicine 2019 17:185

    Content type: Research Published on: 3 June 2019

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  • Pre-clinical evaluation of Minnelide as a therapy for acute myeloid leukemia

    There is an urgent need for novel and effective treatment options for acute myeloid leukemia (AML). Triptolide, a diterpenoid tri-epoxide compound isolated from the herb Tripterygium wilfordii and its water-solub...

    Authors: Bhuwan Giri, Vineet K. Gupta, Brianna Yaffe, Shrey Modi, Pooja Roy, Vrishketan Sethi, Shweta P. Lavania, Selwyn M. Vickers, Vikas Dudeja, Sulagna Banerjee, Justin Watts and Ashok Saluja

    Citation: Journal of Translational Medicine 2019 17:163

    Content type: Research Published on: 20 May 2019

    The Correction to this article has been published in Journal of Translational Medicine 2019 17:301

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  • Blood cell transcript levels in 5-year-old children as potential markers of breastfeeding effects in those small for gestational age at birth

    Nutrition of the newborn during the early postnatal period seems to be of capital importance and there is clinical evidence showing the protective effect of breastfeeding compared with formula feeding on child...

    Authors: Julio Alvarez-Pitti, Maria Amparo Ros-Forés, Ana Bayo-Pérez, Mariona Palou, Empar Lurbe, Andreu Palou and Catalina Picó

    Citation: Journal of Translational Medicine 2019 17:145

    Content type: Research Published on: 7 May 2019

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  • Remote ischemic preconditioning attenuates intestinal mucosal damage: insight from a rat model of ischemia–reperfusion injury

    Remote ischemic preconditioning (RIPC) is a phenomenon, whereby repeated, non-lethal episodes of ischemia to an organ or limb exert protection against ischemia–reperfusion (I/R) injury in distant organs. Despi...

    Authors: Lars Hummitzsch, Karina Zitta, Rouven Berndt, Yuk Lung Wong, Rene Rusch, Katharina Hess, Thilo Wedel, Matthias Gruenewald, Jochen Cremer, Markus Steinfath and Martin Albrecht

    Citation: Journal of Translational Medicine 2019 17:136

    Content type: Research Published on: 29 April 2019

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  • RIPK1 suppresses apoptosis mediated by TNF and caspase-3 in intervertebral discs

    Low back pain has become a serious social and economic burden and the leading cause of disability worldwide. Among a variety of pathophysiological triggers, intervertebral disc (IVD) degeneration plays a prima...

    Authors: Xubin Qiu, Ming Zhuang, Ziwen Lu, Zhiwei Liu, Dong Cheng, Chenlei Zhu and Jinbo Liu

    Citation: Journal of Translational Medicine 2019 17:135

    Content type: Research Published on: 27 April 2019

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  • Compound α-keto acid tablet supplementation alleviates chronic kidney disease progression via inhibition of the NF-kB and MAPK pathways

    Keto-analogues administration plays an important role in clinical chronic kidney disease (CKD) adjunctive therapy, however previous studies on their reno-protective effect mainly focused on kidney pathological...

    Authors: Meng Wang, Huzi Xu, Octavia Li-Sien Chong Lee Shin, Li Li, Hui Gao, Zhi Zhao, Fan Zhu, Han Zhu, Wangqun Liang, Kun Qian, Chunxiu Zhang, Rui Zeng, Hanjing Zhou and Ying Yao

    Citation: Journal of Translational Medicine 2019 17:122

    Content type: Research Published on: 11 April 2019

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  • Spray drying OZ439 nanoparticles to form stable, water-dispersible powders for oral malaria therapy

    OZ439 is a new chemical entity which is active against drug-resistant malaria and shows potential as a single-dose cure. However, development of an oral formulation with desired exposure has proved problematic...

    Authors: Kurt D. Ristroph, Jie Feng, Simon A. McManus, Yingyue Zhang, Kai Gong, Hanu Ramachandruni, Claire E. White and Robert K. Prud’homme

    Citation: Journal of Translational Medicine 2019 17:97

    Content type: Research Published on: 22 March 2019

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  • Dermal tissue remodeling and non-osmotic sodium storage in kidney patients

    Excess dietary sodium is not only excreted by the kidneys, but can also be stored by non-osmotic binding with glycosaminoglycans in dermal connective tissue. Such storage has been associated with dermal inflam...

    Authors: Ryanne S. Hijmans, Marco van Londen, Kwaku A. Sarpong, Stephan J. L. Bakker, Gerjan J. Navis, Twan T. R. Storteboom, Wilhelmina H. A. de Jong, Robert A. Pol and Jacob van den Born

    Citation: Journal of Translational Medicine 2019 17:88

    Content type: Research Published on: 18 March 2019

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  • Diagnostic sensitivity of 2-day cardiopulmonary exercise testing in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

    There are no known objective biomarkers to assist with the diagnosis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). A small number of studies have shown that ME/CFS patients exhibit an earlier...

    Authors: Maximillian J. Nelson, Jonathan D. Buckley, Rebecca L. Thomson, Daniel Clark, Richard Kwiatek and Kade Davison

    Citation: Journal of Translational Medicine 2019 17:80

    Content type: Research Published on: 14 March 2019

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  • Chromosome screening using culture medium of embryos fertilised in vitro: a pilot clinical study

    Previous studies from this as well as other research groups suggested that non-invasive chromosome screening (NICS) with embryo culture medium can be used to identify chromosomal ploidy and chromosomal abnorma...

    Authors: Rui Fang, Weimin Yang, Xin Zhao, Fang Xiong, Caiqing Guo, Jianping Xiao, Li Chen, Xiaoqing Song, Honghua Wang, Jie Chen, Xiao Xiao, Bing Yao and Li-Yi Cai

    Citation: Journal of Translational Medicine 2019 17:73

    Content type: Research Published on: 8 March 2019

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  • Evaluation of endoscopic visible light spectroscopy: comparison with microvascular oxygen tension measurements in a porcine model

    Visible light spectroscopy (VLS) is a technique used to measure the mucosal oxygen saturation during upper gastrointestinal endoscopy to evaluate mucosal ischemia, however in vivo validation is lacking. We aim...

    Authors: Rinse Ubbink, Louisa J. D. van Dijk, Desirée van Noord, Tanja Johannes, Patricia A. C. Specht, Marco J. Bruno and Egbert G. Mik

    Citation: Journal of Translational Medicine 2019 17:65

    Content type: Research Published on: 28 February 2019

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  • How stakeholder engagement influenced a randomized comparative effectiveness trial testing two Diabetes Prevention Program interventions in a Marshallese Pacific Islander Community

    Marshallese face significant health disparities, with particularly high rates of type 2 diabetes. Engaging stakeholders in the research process is essential to reduce health inequities.

    Authors: Pearl A. McElfish, Britni L. Ayers, Holly C. Felix, Christopher R. Long, Zoran Bursac, Joseph Keawe‘aimoku Kaholokula, Sheldon Riklon, Williamina Bing, Anita Iban and Karen Hye-cheon Kim Yeary

    Citation: Journal of Translational Medicine 2019 17:42

    Content type: Research Published on: 11 February 2019

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  • Revisiting IDO and its value as a predictive marker for anti-PD-1 resistance

    Botticelli et al. proposed the activity of indoleamine-2,3-dioxygenase 1 (IDO) as a potential mechanism and predictive marker for primary resistance against anti-PD-1 treatment in the context of non-small cell...

    Authors: Peter Kim Moon, Stephanie Tran and Paras Singh Minhas

    Citation: Journal of Translational Medicine 2019 17:31

    Content type: Commentary Published on: 18 January 2019

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  • Systemic immune-inflammation index predicts prognosis of patients with advanced pancreatic cancer

    Systemic inflammation and immune dysfunction have been proved to be associated with cancer progression and metastasis in various malignancies. The aim of this retrospective study was to evaluate the prognostic...

    Authors: Ke Zhang, Yong-Qiang Hua, Dan Wang, Lian-Yu Chen, Cai-Jun Wu, Zhen Chen, Lu-Ming Liu and Hao Chen

    Citation: Journal of Translational Medicine 2019 17:30

    Content type: Research Published on: 18 January 2019

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  • In vitro effects of interleukin (IL)-1 beta inhibition on the epithelial-to-mesenchymal transition (EMT) of renal tubular and hepatic stellate cells

    The epithelial to mesenchymal transition (EMT) is a multi-factorial biological mechanism involved in renal and hepatic fibrosis and the IL-1 beta has been assumed as a mediator of this process although data ar...

    Authors: Valentina Masola, Amedeo Carraro, Simona Granata, Lorenzo Signorini, Gloria Bellin, Paola Violi, Antonio Lupo, Umberto Tedeschi, Maurizio Onisto, Giovanni Gambaro and Gianluigi Zaza

    Citation: Journal of Translational Medicine 2019 17:12

    Content type: Research Published on: 7 January 2019

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  • An innovative total temporomandibular joint prosthesis with customized design and 3D printing additive fabrication: a prospective clinical study

    Total temporomandibular joint (TMJ) prosthesis is an effective and reliable method of joint reconstruction. However, there is still an urgent need to design a new TMJ prosthesis because of no commercially avai...

    Authors: JiSi Zheng, XuZhuo Chen, WenBo Jiang, ShanYong Zhang, MinJie Chen and Chi Yang

    Citation: Journal of Translational Medicine 2019 17:4

    Content type: Research Published on: 3 January 2019

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  • FGFR1 expression defines clinically distinct subtypes in pancreatic cancer

    The clinical significance of fibroblast growth factor receptor 1 (FGFR1) protein expression in pancreatic cancer is largely unknown. In this study, we aimed investigate the clinical significance of FGFR1 expre...

    Authors: Farhan Haq, You-Na Sung, Inkeun Park, Mahmood Akhtar Kayani, Faizah Yousuf, Seung-Mo Hong and Sung-Min Ahn

    Citation: Journal of Translational Medicine 2018 16:374

    Content type: Research Published on: 28 December 2018

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  • Diffusion-weighted imaging and diffusion kurtosis imaging for early evaluation of the response to docetaxel in rat epithelial ovarian cancer

    To investigate diffusion-weighted magnetic imaging (DWI) and diffusion kurtosis magnetic imaging (DKI) for the early detection of the response to docetaxel (DTX) chemotherapy in rat epithelial ovarian cancer (...

    Authors: Su-juan Yuan, Tian-kui Qiao and Jin-Wei Qiang

    Citation: Journal of Translational Medicine 2018 16:340

    Content type: Research Published on: 5 December 2018

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  • Autoimmune disorders but not heparin are associated with cell-free fetal DNA test failure

    Recent studies have suggested a possible association between heparin treatment at the time of cell-free DNA (cfDNA) testing and a non-reportable result. However, these studies lack of proper methodology and ha...

    Authors: Yohann Dabi, Sarah Guterman, Jacques C. Jani, Alexandra Letourneau, Adèle Demain, Pascale Kleinfinger, Laurence Lohmann, Jean-Marc Costa and Alexandra Benachi

    Citation: Journal of Translational Medicine 2018 16:335

    Content type: Research Published on: 3 December 2018

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  • Mutational and phenotypic spectrum of OTOF-related auditory neuropathy in Koreans: eliciting reciprocal interaction between bench and clinics

    While auditory neuropathy spectrum disorder (ANSD) is a heterogeneous disorder and its management quite varies depending upon the etiology, even including self-resolution, OTOF is an important molecular etiology ...

    Authors: Bong Jik Kim, Jeong Hun Jang, Jin Hee Han, Hye-Rim Park, Doo Yi Oh, Seungmin Lee, Min Young Kim, Ah Reum Kim, Chung Lee, Nayoung K. D. Kim, Woong-Yang Park, Yun-Hoon Choung and Byung Yoon Choi

    Citation: Journal of Translational Medicine 2018 16:330

    Content type: Research Published on: 27 November 2018

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  • Therapeutic value of surgical paraaortic staging in locally advanced cervical cancer: a multicenter cohort analysis from the FRANCOGYN study group

    The prognostic impact of surgical paraaortic staging remains unclear in patients with locally advanced cervical cancer (LACC). The objective of our study was to evaluate the survival impact of surgical staging...

    Authors: Yohann Dabi, Vanille Simon, Xavier Carcopino, Sofiane Bendifallah, Lobna Ouldamer, Vincent Lavoue, Geoffroy Canlorbe, Emilie Raimond, Charles Coutant, Olivier Graesslin, Pierre Collinet, Alexandre Bricou, Emile Daraï, Cyrille Huchon, Marcos Ballester, Bassam Haddad…

    Citation: Journal of Translational Medicine 2018 16:326

    Content type: Research Published on: 26 November 2018

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  • Possibility of avoiding axillary lymph node dissection by immune microenvironment monitoring in preoperative chemotherapy for breast cancer

    The diagnosis of metastasis by sentinel lymph node biopsy (SLNB) in early breast cancer surgery provides an accurate view of the state of metastases to the axillary lymph nodes, and it has now become the stand...

    Authors: Koji Takada, Shinichiro Kashiwagi, Wataru Goto, Yuka Asano, Katsuyuki Takahashi, Hisakazu Fujita, Tsutomu Takashima, Shuhei Tomita, Kosei Hirakawa and Masaichi Ohira

    Citation: Journal of Translational Medicine 2018 16:318

    Content type: Research Published on: 19 November 2018

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    The prognosis of breast cancer and the treatment response to neoadjuvant chemotherapy (NAC) differ depending on the intrinsic molecular subtypes. We evaluated the prognostic significance of immunohistological ...

    Authors: Wataru Goto, Shinichiro Kashiwagi, Koji Takada, Yuka Asano, Katsuyuki Takahashi, Hisakazu Fujita, Tsutomu Takashima, Shuhei Tomita, Kosei Hirakawa and Masaichi Ohira

    Citation: Journal of Translational Medicine 2018 16:307

    Content type: Research Published on: 9 November 2018

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  • Is it possible to overcome issues of external validity in preclinical animal research? Why most animal models are bound to fail

    The pharmaceutical industry is in the midst of a productivity crisis and rates of translation from bench to bedside are dismal. Patients are being let down by the current system of drug discovery; of the sever...

    Authors: Pandora Pound and Merel Ritskes-Hoitinga

    Citation: Journal of Translational Medicine 2018 16:304

    Content type: Review Published on: 7 November 2018

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  • Podocalyxin-like protein as a predictive biomarker for benefit of neoadjuvant chemotherapy in resectable gastric and esophageal adenocarcinoma

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    Authors: David Borg, Anna H. Larsson, Charlotta Hedner, Björn Nodin, Anders Johnsson and Karin Jirström

    Citation: Journal of Translational Medicine 2018 16:290

    Content type: Research Published on: 24 October 2018

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  • Analysis of circulating tumour cell and the epithelial mesenchymal transition (EMT) status during eribulin-based treatment in 22 patients with metastatic breast cancer: a pilot study

    Liquid biopsy approaches, such as measuring circulating tumour cells (CTCs), have recently been introduced in several clinical studies. However, the development of CTCs as a predictive marker for treatment eff...

    Authors: Yoshiya Horimoto, Emi Tokuda, Fumi Murakami, Toshitaka Uomori, Takanori Himuro, Katsuya Nakai, Gotaro Orihata, Kotaro Iijima, Shinsaku Togo, Hideo Shimizu and Mitsue Saito

    Citation: Journal of Translational Medicine 2018 16:287

    Content type: Research Published on: 20 October 2018

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  • The development of a Biobank of cancer tissue samples from World Trade Center responders

    World Trade Center(WTC) responders were exposed to mixture of dust, smoke, chemicals and carcinogens. Studies of cancer incidence in this population have reported elevated risks of cancer compared to the gene...

    Authors: Wil Lieberman-Cribbin, Stephanie Tuminello, Christina Gillezeau, Maaike van Gerwen, Rachel Brody, Michael Donovan and Emanuela Taioli

    Citation: Journal of Translational Medicine 2018 16:280

    Content type: Research Published on: 11 October 2018

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  • The role of diffusion tensor imaging as an objective tool for the assessment of motor function recovery after paraplegia in a naturally-occurring large animal model of spinal cord injury

    Traumatic spinal cord injury (SCI) results in sensory and motor function impairment and may cause a substantial social and economic burden. For the implementation of novel treatment strategies, parallel develo...

    Authors: Adriano Wang-Leandro, Marc K. Hobert, Sabine Kramer, Karl Rohn, Veronika M. Stein and Andrea Tipold

    Citation: Journal of Translational Medicine 2018 16:258

    Content type: Research Published on: 17 September 2018

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  • The diagnostic value of [18F]-FDG-PET/CT in assessment of radiation renal injury in Tibet minipigs model

    Radiation-induced kidney damage can severely affect renal function, and have a serious impact on glucose reabsorption. Fluoro-2-deoxyglucose positron emission tomography (FDG-PET) is routinely utilized for met...

    Authors: Yu-Guang Tian, Min Yue, Bayaer Nashun, Shao-Jie Wu, Wei-Wang Gu and Yu-Jue Wang

    Citation: Journal of Translational Medicine 2018 16:257

    Content type: Research Published on: 17 September 2018

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